Keiji Nogami Selected Research

von Willebrand Factor

12/2023	Hemostatic potential of recombinant von Willebrand factor and standard or pegylated extended half-life recombinant factor VIII on thrombus formation under high shear flow.
9/2022	Emicizumab enhances thrombus formation in vitro under high shear flow conditions in whole blood from patients with type 1 and type 3 von Willebrand disease.
3/2021	Emicizumab improves thrombus formation of type 2A von willebrand disease under high shear condition.
2/2021	A microchip flow-chamber assay screens congenital primary hemostasis disorders.
1/2021	Activated factor VIII-mimicking effect by emicizumab on thrombus formation in type 2N von Willebrand disease under high shear flow conditions.
3/2020	Evaluation of clinical severity in patients with type 2N von Willebrand disease using microchip-based flow-chamber system.
7/2019	Involvement of the ADAMTS13-VWF axis in acute Kawasaki disease and effects of intravenous immunoglobulin.
5/2019	Whole blood ristocetin-induced platelet impedance aggregometry does not reflect clinical severity in patients with type 1 von Willebrand disease.
9/2016	Influenza-associated thrombotic microangiopathy with unbalanced von Willebrand factor and a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 levels in a heterozygous protein S-deficient boy.
2/2015	Optimization of the automated, CS-2000i™ method for measuring low levels of von Willebrand factor ristocetin cofactor activity (VWF:RCo).

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Keiji Nogami Research Topics

Disease

83	Hemophilia A (Haemophilia) 12/2024 - 05/2005
51	Hemorrhage 12/2023 - 11/2014
16	Thrombosis (Thrombus) 12/2023 - 09/2010
6	Disseminated Intravascular Coagulation 03/2024 - 06/2018
6	Thrombophilia 12/2023 - 07/2021
6	Thrombotic Microangiopathies 03/2021 - 09/2016
4	Hemophilia B (Haemophilia B) 03/2023 - 01/2017
4	Disease Progression 08/2022 - 01/2020
4	Thromboembolism 01/2020 - 01/2019
3	Sepsis (Septicemia) 03/2024 - 09/2020
3	Metrorrhagia (Spotting) 03/2024 - 01/2020
3	Body Weight (Weight, Body) 08/2023 - 05/2016
3	Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome) 09/2022 - 02/2017
3	Type 2 von Willebrand Disease 03/2021 - 03/2020
3	Joint Diseases (Joint Disease) 01/2020 - 11/2015
2	Infections 04/2024 - 03/2021
2	Drug-Related Side Effects and Adverse Reactions 12/2023 - 03/2023
2	Pain (Aches) 11/2023 - 01/2023
2	Intracranial Hemorrhages (Intracranial Hemorrhage) 04/2023 - 09/2022
2	Venous Thrombosis (Deep-Vein Thrombosis) 01/2023 - 01/2023
2	Streptococcal Infections (Streptococcal Infection) 08/2022 - 01/2018
2	Protein C Deficiency 07/2021 - 06/2019
2	Autoimmune Diseases (Autoimmune Disease) 03/2021 - 01/2015
2	von Willebrand Diseases (von Willebrand's Disease) 05/2019 - 02/2015
2	Myocardial Infarction 12/2012 - 09/2010
1	Pruritus (Itching) 12/2024
1	familial juvenile Nephronophthisis 04/2024
1	Fever (Fevers) 04/2024
1	Suppuration 04/2024
1	Chronic Kidney Failure (Chronic Renal Failure) 04/2024
1	Bacterial Infections (Bacterial Infection) 11/2023
1	Musculoskeletal Abnormalities 06/2023
1	Hypogonadism (Hypergonadotropic Hypogonadism) 01/2023
1	Activated Protein C Resistance (APC Resistance) 01/2023
1	Infantile Spasms (West Syndrome) 09/2022
1	Type 3 von Willebrand Disease 09/2022

Drug/Important Bio-Agent (IBA)

45	emicizumabIBA 04/2024 - 11/2014
36	Factor VIII (Coagulation Factor VIII)IBA 12/2024 - 05/2005
31	Hemostatics (Antihemorrhagics)IBA 03/2024 - 11/2014
12	AnticoagulantsIBA 12/2023 - 11/2015
11	Thrombin FDA Link 12/2023 - 12/2009
10	von Willebrand FactorIBA 12/2023 - 02/2015
9	prothrombin complex concentrates (PPSB)IBA 03/2021 - 01/2007
8	Blood Coagulation Factors (Coagulation Factor)IBA 01/2022 - 01/2007
7	Protein CIBA 12/2023 - 10/2018
7	CoagulantsIBA 10/2023 - 01/2020
7	Fibrinolysin FDA Link 09/2022 - 07/2017
7	FibrinIBA 08/2022 - 06/2018
6	Factor X (Stuart Factor)IBA 04/2024 - 06/2013
6	Thromboplastin (Tissue Factor)IBA 07/2022 - 12/2009
5	Dacarbazine (DIC)FDA LinkGeneric 03/2024 - 06/2018
4	Monoclonal AntibodiesIBA 03/2024 - 10/2017
4	recombinant FVIIa (rFVIIa)FDA Link 03/2024 - 01/2020
4	Protein SIBA 12/2023 - 09/2016
4	AutoantibodiesIBA 01/2020 - 02/2012
3	AntithrombinsIBA 12/2023 - 01/2022
3	Fibrinogen (Factor I)FDA Link 03/2023 - 06/2018
3	Factor IX (Coagulation Factor IX)FDA LinkGeneric 03/2023 - 01/2022
3	Factor V (Coagulation Factor V)IBA 01/2023 - 01/2017
3	ThrombomodulinIBA 01/2023 - 01/2022
3	Immunoglobulin G (IgG)IBA 09/2022 - 01/2018
2	recombinant factor VIII N8IBA 12/2024 - 08/2018
2	Factor VIIa (Activated Factor VII)IBA 03/2024 - 03/2023
2	Proteins (Proteins, Gene)FDA Link 12/2023 - 07/2022
2	Neutralizing AntibodiesIBA 11/2023 - 11/2014
2	lipoprotein-associated coagulation inhibitor (TFPI)IBA 08/2023 - 01/2014
2	concizumabIBA 08/2023 - 01/2023
2	fitusiranIBA 01/2023 - 01/2019
2	AntibodiesIBA 09/2022 - 03/2021
2	Prothrombin (Factor II)IBA 08/2022 - 01/2020
2	Lupus Coagulation Inhibitor (Lupus Anticoagulant)IBA 06/2021 - 03/2021
2	Factor VIIIaIBA 03/2021 - 01/2021
2	CollagenIBA 02/2021 - 03/2020
2	factor VIII-Fc fusion proteinIBA 05/2020 - 01/2016
2	Ellagic AcidIBA 01/2020 - 12/2009
2	Factor IXa (Coagulation Factor IXa)IBA 01/2020 - 11/2014
1	6-pyruvoyltetrahydropterin synthase (PTPS)IBA 12/2024
1	MC710IBA 03/2023
1	marstacimabIBA 01/2023
1	2019-nCoV Vaccine mRNA-1273IBA 01/2023
1	Testosterone (Sustanon)FDA Link 01/2023
1	Adrenocorticotropic Hormone (ACTH)FDA Link 09/2022
1	butyl phosphorotrithioate (DEF)IBA 09/2022
1	PlasminogenIBA 08/2022
1	Streptokinase FDA Link 08/2022

Therapy/Procedure

33	Therapeutics 12/2024 - 01/2007
3	Liver Transplantation 07/2021 - 01/2016
2	Operative Surgical Procedures 03/2024 - 10/2023
2	Tooth Extraction (Tooth Extractions) 01/2023 - 01/2021
2	Synovectomy 06/2021 - 08/2018
2	Intravenous Infusions 01/2021 - 05/2016
2	Subcutaneous Infusions 01/2020 - 05/2016
2	Injections 08/2018 - 11/2014
2	Intravenous Administration 01/2017 - 01/2016
1	Renal Dialysis (Hemodialysis) 04/2024
1	Peritoneal Dialysis 04/2024
1	Catheters 04/2024
1	Drug Tapering 03/2023
1	Minor Surgical Procedures (Minor Surgery) 01/2023
1	Splints (Splint) 01/2023